Dr. Stephen Sideroff is an internationally recognized expert in resilience, optimal performance, addiction, neurofeedback and alternative approaches to stress and mental health.
He is Associate Professor in the Department of Psychiatry & Biobehavioral Sciences, with a joint appointment in the Department of Rheumatology at UCLA’s School of Medicine, as well as the Director of the Raoul Wallenberg Institute of Ethics.
Dr Robert Lufkin, is a clinical Professor at the USC Keck School of Medicine. Has served as Full Professor at both the UCLA David Geffen School of Medicine and the USC Keck School of Medicine with a current academic focus on the applied science of longevity.
In addition to being a practicing physician, he is author of over 200 peer reviewed scientific papers, 32 book chapters and 13 books that are available in six languages.
Dr. Robert has given invited lectures/keynotes around the world, and was named one of the ‘100 Most Creative People in Los Angeles’ by Buzz Magazine.
03:22 Dr Sideroff Background
- Helps people deal with stress
- Sinificant factor in physical and emotional health
- Developed a model of resilience with 9 steps
- Helps people become more resilient
05:07 Dr Robert Lufkin Background
- Mom was a dietitian
- Went to medical school and trained as a radiologist
- Got many diseases in mid-life…pre-diabetes, gout, hyperlipidemia
- He realized his lifestyle was driving these diseases
- Steve and Robert are working together to integrate the physical and mental aspects required for longevity
08:12 Dr Lufkin Is Writing A Book Called “Lies I Told In Medical School”
- Saturated fats were vilified in medical school – is a lie
- Type 2 diabetes can be managed by insulin – is a lie
- Stress management was not taught in medical school
- Fight or flight stress response is being activated for all the wrong reasons
- The childhood and adult environments are very different – childhood patterns play out in adulhood
17:00 Does The Body Influence The Mind?
- Keto-diet may help with clinical depression
- Ketosis can decrease inflammation and influence brain health
- There is increasing evidence that the connection works both ways
19:22 How Do You Identify Subconscious Patterns From Early Childhood?
- Reflect on the inner voices you hear all day
- That voice is almost always wrong because its from childhood
- It’s important to change the internal parent – so you can love yourself
25:00 How Does Cortisol Or Stress Influence Methylation?
- 30% of methylation sites are influenced by cortisol
- This is a significant driver in aging and longevity
- Very important to fix stress patterns
27:05 Can You Use Your Thoughts To Reverse Aging?
- Dr Sideroff’s biological age is 20 years younger
- When you turn on stress response, your body uses the energy to handle stress instead of working optimally – so you age faster
- The Path: Mastering The 9 Pillars Of Resilience & Success
31:40 Rapamycin For Longevity: What’s The Story Of This Drug?
- The rapamycin bacteria was found on a remote island initially
- 30 years later, it was found to be effective for longevity
- Targets a protein called TOR in the human body
34:37 How does TOR work?
- Nutrient sensing switch that tells the cells to grow if nutirients are available and also drives up inflammation
- Whennutrients are low, body slows down growth and inflammation and turns up repair
- Carbs and insulin turn up growth
36:30 Rapamycin Turns Down Immune System…Is That Good?
- FDA approved rapamycin for kidney transplants as an immune suppressant
- It slows atherosclrosis when used in heart stents
- Treats 8 different types of cancers
- Got approved as a skin cream and can rejuvenate collagen
- There seem to be good use cases for rapamycin for longevity
38:30 What’s The Right Dose Of Rapamycin?
- Daily dose is for reducing immunity for kidney transplants
- For longevity, its used once a week as an immune enhancement dose
- Half life is just a matter of hours
39:27 What Age Groups Are Using Rapamycin?
- Typically people that are 40 or above
- When rapamycin is used even late in life in animals, there are dramatic increases in longevity
40:55 How Can Someone Get Rapacymin If They Want To Start Taking It?
- Must be used under supervision of rapamycin
- Some companies are offering rapamycin in a tele-medicine format
43:22 Do All The Benefits Come From Restricting mTOR?
- Yes, seems to turn down mTOR
- Turns down risk of heart disease, cancer, alzheimers
- Can delay menopause in animal models
45:38 Are Rapalogs Going To Be Better Than Rapamycin?
- Currently, rapamycin is used because it’s FDA approved
- There aren’t a lot of side effects with rapacymin, so rapalogs may never take off
- At the moment, rapacymin for longevity is best
47:40 What Are The Guests’ Predictions On Longevity?
- Making good lifestyle choices is huge
- Cellular reprogramming is very exciting
- Plus things we don’t even see coming