Rapamycin For Longevity: Is It The Best Drug? Plus The Importance Of Mind Body Connection For A Long Life

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Dr. Stephen Sideroff is an internationally recognized expert in resilience, optimal performance, addiction, neurofeedback and alternative approaches to stress and mental health.

He is Associate Professor in the Department of Psychiatry & Biobehavioral Sciences, with a joint appointment in the Department of Rheumatology at UCLA’s School of Medicine, as well as the Director of the Raoul Wallenberg Institute of Ethics.

Dr Robert Lufkin, is a clinical Professor at the USC Keck School of Medicine. Has served as Full Professor at both the UCLA David Geffen School of Medicine and the USC Keck School of Medicine with a current academic focus on the applied science of longevity.

In addition to being a practicing physician, he is author of over 200 peer reviewed scientific papers, 32 book chapters and 13 books that are available in six languages.

Dr. Robert has given invited lectures/keynotes around the world, and was named one of the ‘100 Most Creative People in Los Angeles’ by Buzz Magazine.

03:22 Dr Sideroff Background

Helps people deal with stress
Sinificant factor in physical and emotional health
Developed a model of resilience with 9 steps
Helps people become more resilient

05:07 Dr Robert Lufkin Background

Mom was a dietitian
Went to medical school and trained as a radiologist
Got many diseases in mid-life…pre-diabetes, gout, hyperlipidemia
He realized his lifestyle was driving these diseases
Steve and Robert are working together to integrate the physical and mental aspects required for longevity

08:12 Dr Lufkin Is Writing A Book Called “Lies I Told In Medical School”

Saturated fats were vilified in medical school – is a lie
Type 2 diabetes can be managed by insulin – is a lie
Stress management was not taught in medical school
Fight or flight stress response is being activated for all the wrong reasons
The childhood and adult environments are very different – childhood patterns play out in adulhood

17:00 Does The Body Influence The Mind?

Keto-diet may help with clinical depression
Ketosis can decrease inflammation and influence brain health
There is increasing evidence that the connection works both ways

19:22 How Do You Identify Subconscious Patterns From Early Childhood?

Reflect on the inner voices you hear all day
That voice is almost always wrong because its from childhood
It’s important to change the internal parent – so you can love yourself

25:00 How Does Cortisol Or Stress Influence Methylation?

30% of methylation sites are influenced by cortisol
This is a significant driver in aging and longevity
Very important to fix stress patterns

27:05 Can You Use Your Thoughts To Reverse Aging?

Dr Sideroff’s biological age is 20 years younger
When you turn on stress response, your body uses the energy to handle stress instead of working optimally – so you age faster
The Path: Mastering The 9 Pillars Of Resilience & Success

31:40 Rapamycin For Longevity: What’s The Story Of This Drug?

The rapamycin bacteria was found on a remote island initially
30 years later, it was found to be effective for longevity
Targets a protein called TOR in the human body

34:37 How does TOR work?

Nutrient sensing switch that tells the cells to grow if nutirients are available and also drives up inflammation
Whennutrients are low, body slows down growth and inflammation and turns up repair
Carbs and insulin turn up growth

36:30 Rapamycin Turns Down Immune System…Is That Good?

FDA approved rapamycin for kidney transplants as an immune suppressant
It slows atherosclrosis when used in heart stents
Treats 8 different types of cancers
Got approved as a skin cream and can rejuvenate collagen
There seem to be good use cases for rapamycin for longevity

38:30 What’s The Right Dose Of Rapamycin?

Daily dose is for reducing immunity for kidney transplants
For longevity, its used once a week as an immune enhancement dose
Half life is just a matter of hours

39:27 What Age Groups Are Using Rapamycin?

Typically people that are 40 or above
When rapamycin is used even late in life in animals, there are dramatic increases in longevity

40:55 How Can Someone Get Rapacymin If They Want To Start Taking It?

Must be used under supervision of rapamycin
Some companies are offering rapamycin in a tele-medicine format

43:22 Do All The Benefits Come From Restricting mTOR?

Yes, seems to turn down mTOR
Turns down risk of heart disease, cancer, alzheimers
Can delay menopause in animal models

45:38 Are Rapalogs Going To Be Better Than Rapamycin?

Currently, rapamycin is used because it’s FDA approved
There aren’t a lot of side effects with rapacymin, so rapalogs may never take off
At the moment, rapacymin for longevity is best