On this episode, we discuss the importance of Nicotinamide Adenine Nucleotide (NAD) in your body and why it’s essential to keep up your levels of NAD for anti-aging and a healthier, longer life.
Tom Ingoglia’s life changed when he was infected with Lyme disease because he experienced adverse drug reactions that spiraled into drug addiction. But his rock bottom was losing half his family in the same week. Tom dedicated himself to healing over eight years, found intravenous NAD⁺ therapy, and miraculously regained his health. He went on to spearhead IV NAD therapies in the clinic he created.
Now, he’s built 7 longevity companies to try to bring revolutionary therapies to the world. These organizations work together in hopes to shed light on therapies that have global impact.
NAD Background: NAD stands for Nicotinamide Adenine Nucleotide. It is essential to the creation of energy in the body and coordinating cellular processes. It’s a critical coenzyme found in every cell in your body. NAD is involved in hundreds of metabolic processes like mitochondrial health, cellular energy, DNA repair, assisting proteins and other enzymes in the upkeep of your body.
How Did Tom Find NAD?
- Had a reaction to antibiotics on a vacation
- Was bedridden for 2 years
- Tried many therapies and none worked
- NAD helped Tom get back to normal
- Dr David Sinclair’s article came out 6 months after Tom received IV NAD treatment, which solidified his belief in NAD.13
Why Is NAD So Important For Anti-Aging and Health?
- Repairs DNA damage10 . When your DNA strand within a cell gets damaged, NAD is an important part of the repair process.
- Helps provide more energy6 . NAD is involved in the krebs cycle in the mitochondria.
- Acts as a co-substrate for sirtuins15 . Sirtuins have been identified as genes and enzymes associated with longevity.
- Is a neurotransmitter17
- Is involved in circadian rhythms18
- Is required by CD3819
How Is NAD Made In the Body?
- NAD can be made by the de-novo pathway which starts with the amino acid l-tryptophan (takes 8 steps)
- It can be made by the “Preiss-Handler pathway,” using nicotinic acid (a form of vitamin B3 – also called niacin)
- Unfortunately as we get older, NAD levels start to decline
- This affects all the functions NAD in involved in, thus leading to cellular aging (in addition to the other reasons we age)
How Can You Get NAD From External Sources
- Take NAD precursors in supplement form: Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN)
- Use NAD patches (usually with electrophoresis)
- Use NAD IV’s
- Try NAD sublingual
- Try NAD intranasally
- Try NAD face cream
- We discuss the pros and cons of each form of NAD
Who Are The NAD Pioneers?
- Abram Hoffer14
- Paul O’Hollaren (waiting on info from genealogist)
- Bill Wilson20
- Linus Pauling7
- John P. Cleary9
What’s Tom’s Involvement With NAD?
- Tom has created new products, patches, written a book, making a movie.
- Tom believe patches and IV NAD+ allow NAD+ to enter the cell unencumbered.1,2
- Showing clinical research on NAD with drug addiction.
- And why I chose that versus aging.
- NAD+ helps to metabolize alcohol.8
- NAD+ may help with glutamate excitotoxicity.4
- NAD+ enters astrocytes.3,5,21
- We see this through MRS scans.16 NAD+ precursors don’t seem to enter the brain.12
What Else Does Tom Spend His Free Time On?
- Tom is building a longevity clinic in Costa Rica. It’s about 5 years away.
Where Can You Get NAD Patches?
- Go to Longevity Collective and enter the code FARAZ15 to get a discount
www.Longevitycollective.com — Tom’s supplement company
www.nadtreatmentcenter.com — IV NAD treatment
www.Longevityunderground.org — Tom’s Nonprofit
Documentary link: https://www.untoldmiracle.com/
The New Book: The NAD Miracle: Journey to High Performance, Sobriety, and Higher Consciousness
Bennett James, Berg Jade, Braidy Nady, Broom Susan, Grant Ross, Mestayer Richard, Watson
James. (2019) ,A Pilot Study Investigating Changes in the Human Plasma and Urine
NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+. Frontiers in Aging
Neuroscience, 11, 257. https://doi.org/10.3389/fnagi.2019.00257
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nuclear-mitochondrial communication during aging. Cell, 155(7), 1624–1638.
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Lu, M., Zhu, X. -H., and Chen, W. (2016) In vivo 31P MRS assessment of intracellular NAD
metabolites and NAD+/NADH redox state in human brain at 4 T. NMR Biomed., 29:
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