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On this episode, we discuss the importance of Nicotinamide Adenine Nucleotide (NAD) in your body and why it’s essential to keep up your levels of NAD for anti-aging and a healthier, longer life.

Tom Ingoglia’s life changed when he was infected with Lyme disease because he experienced adverse drug reactions that spiraled into drug addiction. But his rock bottom was losing half his family in the same week. Tom dedicated himself to healing over eight years, found intravenous NAD⁺ therapy, and miraculously regained his health. He went on to spearhead IV NAD therapies in the clinic he created.  

Now, he’s built 7 longevity companies to try to bring revolutionary therapies to the world. These organizations work together in hopes to shed light on therapies that have global impact. 

NAD Background: NAD stands for Nicotinamide Adenine Nucleotide. It is essential to the creation of energy in the body and coordinating cellular processes. It’s a critical coenzyme found in every cell in your body. NAD is involved in hundreds of metabolic processes like mitochondrial health, cellular energy, DNA repair, assisting proteins and other enzymes in the upkeep of your body.

How Did Tom Find NAD?

  • Had a reaction to antibiotics on a vacation
  • Was bedridden for 2 years
  • Tried many therapies and none worked
  • NAD helped Tom get back to normal
  • Dr David Sinclair’s article came out 6 months after Tom received IV NAD treatment, which solidified his belief in NAD.13

Why Is NAD So Important For Anti-Aging and Health?

  • Repairs DNA damage10 . When your DNA strand within a cell gets damaged, NAD is an important part of the repair process.
  • Helps provide more energy6 . NAD is involved in the krebs cycle in the mitochondria.
  • Acts as a co-substrate for sirtuins15 . Sirtuins have been identified as genes and enzymes associated with longevity.
  • Is a neurotransmitter17
  • Is involved in circadian rhythms18
  • Is required by CD3819

How Is NAD Made In the Body?

  • NAD can be made by the de-novo pathway which starts with the amino acid l-tryptophan (takes 8 steps)
  • It can be made by the “Preiss-Handler pathway,” using nicotinic acid (a form of vitamin B3 – also called niacin)
  • Unfortunately as we get older, NAD levels start to decline
  • This affects all the functions NAD in involved in, thus leading to cellular aging (in addition to the other reasons we age)

How Can You Get NAD From External Sources

  • Take NAD precursors in supplement form: Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN)
  • Use NAD patches (usually with electrophoresis)
  • Use NAD IV’s
  • Try NAD sublingual
  • Try NAD intranasally
  • Try NAD face cream
  • We discuss the pros and cons of each form of NAD

Who Are The NAD Pioneers?

  • Abram Hoffer14
  • Paul O’Hollaren (waiting on info from genealogist)
  • Bill Wilson20
  • Linus Pauling7
  • John P. Cleary9

What’s Tom’s Involvement With NAD?

  • Tom has created new products, patches, written a book, making a movie.
  • Tom believe patches and IV NAD+ allow NAD+ to enter the cell unencumbered.1,2
  • Showing clinical research on NAD with drug addiction.
  • And why I chose that versus aging.
  • NAD+ helps to metabolize alcohol.8
  • NAD+ may help with glutamate excitotoxicity.4
  • NAD+ enters astrocytes.3,5,21
  • We see this through MRS scans.16 NAD+ precursors don’t seem to enter the brain.12

What Else Does Tom Spend His Free Time On?

  • Tom is building a longevity clinic in Costa Rica. It’s about 5 years away.

Where Can You Get NAD Patches?

Other Resources

www.Longevitycollective.com — Tom’s supplement company 

www.nadtreatmentcenter.com — IV NAD treatment

www.Longevityunderground.org — Tom’s Nonprofit

Documentary link:  https://www.untoldmiracle.com/

The New Book:  The NAD Miracle:  Journey to High Performance, Sobriety, and Higher Consciousness

2020 RAADfest video

References:

Bennett James, Berg Jade, Braidy Nady, Broom Susan, Grant Ross, Mestayer Richard, Watson 

James. (2019) ,A Pilot Study Investigating Changes in the Human Plasma and Urine 

NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+. Frontiers in Aging 

Neuroscience, 11, 257. https://doi.org/10.3389/fnagi.2019.00257  

Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, 

Condorelli F, Genazzani AA. Characterization of NAD uptake in mammalian cells. 

J Biol Chem. 2008 Mar 7;283(10):6367-74. doi: 10.1074/jbc.M706204200. Epub 

2008 Jan 7. PMID: 18180302.

Braidy N, Grant R, Adams S, Brew BJ, Guillemin GJ. Mechanism for quinolinic acid 

cytotoxicity in human astrocytes and neurons. Neurotox Res. 2009 

Jul;16(1):77-86. doi: 10.1007/s12640-009-9051-z. Epub 2009 Apr 18. PMID: 

19526301.

Braidy, N., Villalva, M. D., & van Eeden, S. (2020). Sobriety and Satiety: Is NAD+ the Answer?. 

Antioxidants (Basel, Switzerland), 9(5), 425. https://doi.org/10.3390/antiox9050425

Bruzzone, S., Guida, L., Zocchi, E., Franco, L. and Flora, A.D. (2001), Connexin 43 hemichannels 

mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells. FASEB J, 15: 10-12. 

https://doi.org/10.1096/fj.00-0566fje

Cantó, C., Menzies, K. J., & Auwerx, J. (2015). NAD(+) Metabolism and the Control of Energy 

Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell metabolism, 22(1), 

31–53. https://doi.org/10.1016/j.cmet.2015.05.023

Carter S. (2019). Origins of Orthomolecular Medicine. Integrative medicine (Encinitas, Calif.), 18(3), 

76–77.

Cederbaum A. I. (2012). Alcohol metabolism. Clinics in liver disease, 16(4), 667–685. 

https://doi.org/10.1016/j.cld.2012.08.002

Cleary, J. P. (1986). The NAD deficiency diseases. Journal of Orthomolecular Medicine, 1(3), 

149–157.

Croteau, D. L., Fang, E. F., Nilsen, H., & Bohr, V. A. (2017). NAD+ in DNA repair and mitochondrial 

maintenance. Cell cycle (Georgetown, Tex.), 16(6), 491–492. 

https://doi.org/10.1080/15384101.2017.1285631

Elton, Catherine. (2019, October 29.) Has Harvard’s David Sinclair Found the Fountain of Youth? Boston 

Magazine. https://www.bostonmagazine.com/health/2019/10/29/david-sinclair/

Frederick, D. W., Loro, E., Liu, L., Davila, A., Jr, Chellappa, K., Silverman, I. M., Quinn, W. J., 3rd, Gosai, 

S. J., Tichy, E. D., Davis, J. G., Mourkioti, F., Gregory, B. D., Dellinger, R. W., Redpath, P., 

Migaud, M. E., Nakamaru-Ogiso, E., Rabinowitz, J. D., Khurana, T. S., & Baur, J. A. (2016). Loss 

of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell 

metabolism, 24(2), 269–282. https://doi.org/10.1016/j.cmet.2016.07.005

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., … Sinclair, 

D. A. (2013). Declining NAD+ induces a pseudohypoxic state disrupting 

nuclear-mitochondrial communication during aging. Cell, 155(7), 1624–1638. 

https://doi.org/10.1016/j.cell.2013.11.037

Hoffer, A., Osmond, H., Callbeck, M. J., & Kahan, I. (1957). Treatment of schizophrenia with nicotinic 

acid and nicotinamide. Journal of Clinical & Experimental Psychopathology, 18, 131–158.

Imai, S. ichiro, & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell 

Biology. Elsevier Ltd. https://doi.org/10.1016/j.tcb.2014.04.002

Lu, M., Zhu, X. -H., and Chen, W. (2016) In vivo 31P MRS assessment of intracellular NAD 

metabolites and NAD+/NADH redox state in human brain at 4 T. NMR Biomed., 29: 

1010– 1017. doi: 10.1002/nbm.3559.

Mutafova-Yambolieva, V. N., Sung, J. H., Hao, X., Chen, H., Zhu, M. X., Wood, J. D., … Sanders, K. 

M. (2007). β-Nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral 

smooth muscle. Proceedings of the National Academy of Sciences of the United States of 

America, 104(41), 16359–16364. https://doi.org/10.1073/pnas.0705510104

Nakahata, Y., & Bessho, Y. (2016). The Circadian NAD+ Metabolism: Impact on Chromatin Remodeling 

and Aging. BioMed research international, 2016, 3208429. https://doi.org/10.1155/2016/3208429

Piedra-Quintero, Z. L., Wilson, Z., Nava, P., & Guerau-de-Arellano, M. (2020). CD38: An 

Immunomodulatory Molecule in Inflammation and Autoimmunity. Frontiers in immunology, 11

597959. https://doi.org/10.3389/fimmu.2020.597959

Rosenthal, Howard. (2017, July 13.) Alcoholics Anonymous Founder Bill Wilson’s Long Lost 

Treatment Paradigm. Psychotherapy. https://www.psychotherapy.net/blog/title/alcoholics-anonymous-founder-bill-wilson-s-long-lost-treatment-paradigm

Wonodi I, Schwarcz R. Cortical kynurenine pathway metabolism: a novel target for 

cognitive enhancement in Schizophrenia. Schizophr Bull. 2010 Mar;36(2):211-8. 

doi: 10.1093/schbul/sbq002. Epub 2010 Feb 10. PMID: 20147364; PMCID: 

PMC2833131.

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